A METHOD FOR THE PREPARATION, ISOLATION AND PURIFI

专利名称：A METHOD FOR THE PREPARATION,

ISOLATION AND PURIFICATION OFPHARMACEUTICALLY APPLICABLE FORMSOF AHU-377

发明人：HALAMA, Ales,ZVATORA, Pavel,DAMMER,

Ondrej,STACH, Jan,ZAPADLO,

Michal,KREJCIK, Lukas,VOSLAR, Michal

申请号：EP15808087.9申请日：20151111公开号：EP3218351B1公开日：20190619

摘要：An isolation and purification method of substances derived from AHU-377 offormula (1), characterized by conversion of the crude substance (1) to well-crystallizingsalts with amines of formula (9) in the environment of a suitable organic solvent, followedby recrystallization of these salts to simultaneously remove chemical impurities, and useof the chemically pure salts of AHU-377 with amines for direct transformation to apharmaceutically applicable form of AHU-377 with alkali metals of formula (10), or withalkaline earth metals of formula (11).

申请人：ZENTIVA K S

地址：CZ

国籍：CZ

代理机构：Jirotkova, Ivana

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